Reproductive Cycle in a Host Cell

Each different picornaviridae virus will use its own different cellular receptors.

• A picornavirus virion attaches to a host cell.


• Uncoating occurs, and the virus' RNA is released into the cytoplasm of the host cell through a membrane channel.
  

• The host cell's transcription processes are shut off to a degree that varies with different picornaviruses, while the IRES helps to make sure the virus' transcription is left untouched.


• Replication occurs in cytoplasm. In vitro transcription studies have suggested 2 possible models by which genome replication might occur:

• RNA is packaged into preformed capsids.


• The viruses are released when cell lysis occurs.
  
  

picture extracted: http://www.microbiologybytes.com/virology/Picornaviruses.html http://gsbs.utmb.edu/microbook/ch042.htm

References:
http://www.microbiologybytes.com/virology/Picornaviruses.html http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/00.052.htm#quickIDX2 http://www.stanford.edu/group/virus/picorna/2004flynn/Picornaviridae2.htm